VISIPRO™ 20-20 – Revolutionary New Eye Health Support
VISIPRO™ 20-20 is an effective and safe way to provide a broad range of advantages for your eye wellness. This advanced vision support formulation contains only 100% clinically researched ingredients that have shown through scientific study to be beneficial in safeguarding ocular health.
The complete VISIPRO formula is a powerful combination of ingredients, each of which has passed rigorous tests for quality and purity. These ingredients are carefully balanced and combined within an easy-to-swallow softgel. Going beyond Vitamin E and Vitamin A – two of the best known vitamins for ocular health – this formulation also contains Lutein and Zeaxanthin. These two potent carotenoids are easy favorites of eye health specialists and are frequently recommended as a part of an overall eye health routine. The sooner you begin this type of strategy, including proper nutrition and supplementation, the sooner you will begin to protect your eyes from various forms of disease and damage.
VISIPRO™ 20-20 pharmaceutical grade softgels are manufactured in a GMP FDA Certified Lab in the United States by Intechra Health. This lets you know that they have been manufactured using the highest possible safety and quality standards as established in the USA.
The Science Behind the VISIPRO 20-20 Formula
Vitamin A (as retinyl acetate)
Vitamin A is a vitamin that has been found to play a vital role in combating oxidative stress on the eyes*. If oxidative stress from free radicals is allowed to damage enough of the cells in the eye, the result is frequently age related macular degeneration (AMD). AMD is currently the top cause of blindness within the developed world.
Despite its common nature, much of AMD is not well understood. Therefore, it is difficult to treat. Due to the delicate nature of the retina, it is particularly susceptible to oxidative stress. However, the antioxidant properties of vitamin A can help to prevent that damage from occurring.
Still, while vitamin A can be obtained through food, it is also frequently found to be deficient in many people. Eye and vision diseases** and symptoms are among the many problems that can occur when the body does not receive a regular adequate supply of this vitamin***.
* Stephen Beatty, FRCOphth, , Hui-Hiang Koh, M Phil, David Henson, PhD, Michael Boulton, PhD. “The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration”. Survey of Ophthalmology. 2000. Volume 45, Issue 2. http://www.sciencedirect.com/science/article/pii/S0039625700001405
** Beitch, Irwin. “The Induction of Keratinization in the Corneal Epithelium A Comparison of the “Dry” and Vitamin A-Deficient Eyes”. Investigative Ophthalmology and Visual Science. 1970. Volume 9, Issue 11. http://iovs.arvojournals.org/article.aspx?articleid=2203477
*** D. S. McLaren, H. A. P. C. Oomen, and H. Escapini. “Ocular manifestations of vitamin-A deficiency in man”. Bulletin of the World Health Organization. 1966. Volume 34, Issue 3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475981/
Vitamin C (as ascorbyl palmitate)
Vitamin C is a powerful antioxidant that plays a vital role in preventing and overcoming oxidative stress on the body, including the eye. This vitamin has been found to be particularly beneficial in counteracting issues regarding oxidation when it comes to various parts of the eye. It has been found to provide protection against this damage that occur as a result of “superoxide and its derivatives produced during normal cellular oxidation.”*
Other research has found that it works very effectively alongside both vitamin A and vitamin E in acting as an antioxidant in general. This combination of three powerful vitamin antioxidants are all included within this formulation.**
More research found that the regular and adequate consumption of vitamin C may lower the risk of the development of advanced or exudative age related macular degeneration (AMD).***
* Varma, S. D., S. Kumar, and R. D. Richards. “Light-induced damage to ocular lens cation pump: prevention by vitamin C”. Proceedings of the National Academy of Sciences of the United States of America. 1979. Volume 76, Issue 7. http://www.pnas.org/content/76/7/3504.short
** Stephen Beatty, FRCOphth, , Hui-Hiang Koh, M Phil, David Henson, PhD, Michael Boulton, PhD. “The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration”. Survey of Ophthalmology. 2000. Volume 45, Issue 2. http://www.sciencedirect.com/science/article/pii/S0039625700001405
***Johanna M. Seddon, MD; Umed A. Ajani, MBBS; Robert D. Sperduto, MD; Rita Hiller, MS; Norman Blair, MD; Thomas C. Burton, MD; Marilyn D. Farber, PhD; Evangelos S. Gragoudas, MD; Julia Haller, MD; Dayton T. Miller, PhD; Lawrence A. Yannuzzi, MD; Walter Willett, MD. “Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration.” Journal of the American Medical Association. 1994. Volume 272. Issue 18. http://jama.jamanetwork.com/article.aspx?articleid=382145
Vitamin E (as dl-alpha-tocopheryl succinate)
Many of us think of vitamin E as a nutrient that benefits the skin, but it also plays an extremely important role in ocular health. Research has shown that daily supplements of this nutrient can also go a long way toward supporting ocular health and preventing eye disease.
Daily supplement with vitamin E supplement does not prevent the development or progression of early or later stages of age related macular degeneration. This was found to be even more beneficial when it was combined with vitamins A and C, which are also both present in VISIPRO. The protection against AMD is exceptionally important because the degeneration is not reversible.
Many people don’t take action to protect themselves against AMD until signs of damage are already present. However, starting early to build up a daily routine of eye care and protection against AMD may make a considerable difference in delaying its onset and reducing any damage it may cause.
Vitamin E was also found to be beneficial to eye health among patients with diabetes. Patients with diabetes are at greater risk of oxidative events which can lead to retinal detachment among other ocular disorders and diseases. The study showed that when the retina is an area that experiences an especially high amount f free radical production under conditions such as diabetes, among others**. Therefore, antioxidant protection can go a long way to protect against those risks.
*Johanna M. Seddon, MD; Umed A. Ajani, MBBS; Robert D. Sperduto, MD; Rita Hiller, MS; Norman Blair, MD; Thomas C. Burton, MD; Marilyn D. Farber, PhD; Evangelos S. Gragoudas, MD; Julia Haller, MD; Dayton T. Miller, PhD; Lawrence A. Yannuzzi, MD; Walter Willett, MD. “Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration.” Journal of the American Medical Association. 1994. Volume 272. Issue 18. http://jama.jamanetwork.com/article.aspx?articleid=382145
** Ignazio Grattagliano, Gianluigi Vendemiale, Francesco Boscia, Tommaso Micelli-Ferrari, Luigi Cardia, Emanuele Altomare. “Oxidative Retinal Products and Ocular Damages in Diabetic Patients”. Free Radical Biology and Medicine. 1998. Volume 25, Issue 3. http://www.sciencedirect.com/science/article/pii/S0891584998000598
Zinc (as zinc oxide)
Zinc is a mineral that is key to good health and is often consumed in food. However, when taken in the proper doses, it can contribute to a strong defense against macular degeneration*. That said, it is meant to be used in combination with other substances in an overall protection against this irreversible condition. This is because in smaller doses it can be helpful but in larger doses it can be toxic.
Therefore, it must be used as a part of a broader strategy to protect eye health. This is because its benefits aren’t exclusively in macular degeneration prevention. It also plays a key role in the body’s ability to absorb vitamin A**, which is the first ingredient in VISIPRO. In fact, the presence of zinc within the body plays a role in several components of the metabolism of vitamin A, not only including its absorption but also in the way it is used.***
* David A. Newsome, MD; Mano Swartz, MD; Nicholas C. Leone, MD; Robert C. Elston, PhD; Earl Miller. “Oral Zinc in Macular Degeneration”. Journal of the American Medical Association. 1998. Volume 106, Issue 2. http://archopht.jamanetwork.com/article.aspx?articleid=637111
** Smith, J. Cecil Jr. “The Vitamin A-Zinc Connection: A Review”. Annals of the New York Academy of Sciences. 1980. Volume 355. http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1980.tb21328.x/abstract
*** Christian, P. and K. P. West Jr. “Interactions between zinc and vitamin A: an update.” The American Journal of Clinical Nutrition. 1998. Volume 68, Issue 2. http://ajcn.nutrition.org/content/68/2/435S.short
Selenium (as L-Selenomethionine)
Selenium is another nutrient that is becoming better understood with each passing year. What is becoming exceptionally well known is that it is associated with a wide range of benefits to ocular health.
In fact, there has been a relationship discovered between the presence of selenium and the ocular health of patients with glaucoma*. Glaucoma is a common eye disease in which the eye pressures continue to climb until this can eventually cause damage to the ocular nerve. While treatment of this disease is possible through various forms of medication and surgery, if left to harm the ocular nerve, the damage to an individual’s vision is irreversible.
In two separate rat studies, the presence of selenium** was found to have an impact on the health and integrity of the retina***. Deficient rats were found to have noticeably greater light damage on their retinas than those who had adequate levels of selenium.
* Bruhn, R L, W D Stamer, L A Herrygers, J M Levine, R J Noecker. “Relationship between glaucoma and selenium levels in plasma and aqueous humour”. British Journal of Ophthalmology. 2009. Volume 93. http://bjo.bmj.com/content/93/9/1155.short
** Stone, William L., Martin L. Katz, Mark Lurie, Michael F. Marmor, Edward A. Dratz “Effects of Dietary Vitamin E and Selenium on Light Damage to the Rat Retina”. 1979. Volume 29, Issue 4. http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.1979.tb07757.x/full
*** Stone, W.L., E.A. Dratza. “Selenium and non-selenium glutathione peroxidase activities in selected ocular and non-ocular rat tissues”. Experimental Eye Research. 1982. Volume 35, Issue 5. http://www.sciencedirect.com/science/article/pii/0014483582900392
Lutein is a carotenoid that is available in food but that we rarely obtain in nearly large enough quantities to play the type of role it can play in our ocular health. Optometrists are recommending supplementation of this nutrient to an increasing degree in order to help to protect eyes and vision against a range of different types of problems. This primarily includes macular degeneration but this substance also helps in a number of other areas of eye health.
One study found that even among older adults, lutein is still effective enough to play an important role in eye health and in the prevention of age related macular disorder and other ocular disorders connected with age. Aside from AMD, lutein was also seen to provide protection against eye problems such as cataracts. The researchers behind the study stated that they believed that the lutein acted as a filter for blue light, which can have wavelengths that are damaging to parts of the eye.*
Another study was able to show that lutein is adequately effective that it could even help in the eyes of patients who had received human donor eyes in transplants.** This reveals a meaningful impact on the health and function of the eye.
* Renzi, Lisa M. MS & Elizabeth J. Johnson PhD. “Lutein and Age-Related Ocular Disorders in the Older Adult”. Journal of Nutrition For the Elderly. 2008. Volume 26, Issue 3-4. http://www.tandfonline.com/doi/abs/10.1300/J052v26n03_07
** Bhosale, Prakash, Da You Zhao, Paul S. Bernstein. “HPLC Measurement of Ocular Carotenoid Levels in Human Donor Eyes in the Lutein Supplementation Era.” Biochemistry and Molecular Biology. 2007. Volume 48. http://iovs.arvojournals.org/article.aspx?articleid=2125334
Zeaxanthin is a nutrient frequently supplemented along with lutein due to their combined benefits for eye health.
One study found that as lutein and zeaxanthin make up the pigment of the eye (the only two carotenoids that are found within the human eye lens) there is an inverse relationship between the presence of those substances and many age related eye issues. Moreover, macular pigment density and lens density had an inverse and age-dependent relationship. Therefore, the study concluded* that obtaining lutein and zeaxanthin through supplementation or diet can, together, slow age-related increases in the density of the lens.
Another study found that the majority of the carotenoids – including lutein and zeaxanthin – that are in the human peripheral retina can also be found within the rod outer segments. Those ROS carotenoids have been linked with soluble or salt-dependently bound proteins**.
Yet another study only underscored the fact that lutein and zeaxanthin are a powerful combination specifically for eye health and the prevention of ocular diseases***. That said, they may also, to a lesser extent, help the body in protecting itself against cardiovascular disease and certain cancers.
* Hammond, Billy R. Jr. PhD, Wooten, Billy, R. PhD, Snodderly, D. Max PhD. “Density of the Human Crystalline Lens is Related to the Macular Pigment Carotenoids, Lutein and Zeaxanthin”. Optometry & Vision Science. 1997. Volume 74, Issue 7. http://journals.lww.com/optvissci/Abstract/1997/07000/Density_of_the_Human_Crystalline_Lens_is_Related.17.aspx
** Olaf Sommerburga, Werner G. Siemsa, John S. Hursta, James W. Lewisa, David S. Kligera & Frederik J.G.M. van Kuijka. “Lutein and zeaxanthin are associated with photoreceptors in the human retina”. Current Eye Research. 1999. Volume 19, Issue 6. http://www.tandfonline.com/doi/abs/10.1076/ceyr.19.6.491.5276
*** Mares-Perlman, Julie A., Amy E. Millen, Tara L. Ficek, and Susan E. Hankinson. “The Body of Evidence to Support a Protective Role for Lutein and Zeaxanthin in Delaying Chronic Disease”. The American Society for Nutritional Sciences. 2002. Volume 132, Issue 3. http://jn.nutrition.org/content/132/3/518S.short